Assay Detail
Binding
CHEMBL619905
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Inhibition of rat polymorphonuclear leukocyte (PMN) 5-Lipoxygenase in vitro
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis of [[(naphthalenylmethoxy)- and [[(quinolinylmethoxy)phenyl]amino]oxoalkanoic acid esters. A novel series of leukotriene D4 antagonists and 5-lipoxygenase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.08 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8747 | REV-5901 | — | 1 | 6.52 |
| CHEMBL33734 | — | — | 1 | 6.22 |
| CHEMBL284706 | — | — | 1 | 6.07 |
| CHEMBL287012 | — | — | 1 | 5.85 |
| CHEMBL285175 | — | — | 1 | 5.72 |
| CHEMBL34106 | — | — | 1 | 5.58 |
| CHEMBL289901 | — | — | 1 | 5.50 |
| CHEMBL33109 | — | — | 1 | 5.28 |
| CHEMBL285624 | — | — | 1 | 5.16 |
| CHEMBL34672 | — | — | 1 | 5.12 |
| CHEMBL286178 | — | — | 1 | 5.02 |
| CHEMBL33322 | — | — | 1 | 4.98 |
| CHEMBL286776 | — | — | 1 | 4.90 |
| CHEMBL34225 | — | — | 1 | 4.90 |
| CHEMBL33167 | — | — | 1 | 4.85 |
| CHEMBL33465 | — | — | 1 | 4.81 |
| CHEMBL34676 | — | — | 1 | 4.80 |
| CHEMBL33437 | — | — | 1 | 4.72 |
| CHEMBL285744 | — | — | 1 | 4.61 |
| CHEMBL32560 | — | — | 1 | 4.58 |
| CHEMBL288778 | — | — | 1 | 4.55 |
| CHEMBL284824 | — | — | 1 | 4.53 |
| CHEMBL34445 | — | — | 1 | 4.45 |
| CHEMBL416039 | — | — | 1 | 4.22 |
| CHEMBL33844 | — | — | 1 | 4.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8747 | REV-5901 | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL33734 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL284706 | — | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL287012 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL285175 | — | IC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL34106 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL289901 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL33109 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL285624 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL34672 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL286178 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL33322 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL286776 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL34225 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL33167 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL33465 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL34676 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL33437 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL285744 | — | IC50 | = | 24600.0 | nM | 4.61 |
| CHEMBL32560 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL288778 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL284824 | — | IC50 | = | 29500.0 | nM | 4.53 |
| CHEMBL34445 | — | IC50 | = | 35200.0 | nM | 4.45 |
| CHEMBL416039 | — | IC50 | = | 60500.0 | nM | 4.22 |
| CHEMBL33844 | — | IC50 | = | 86200.0 | nM | 4.06 |