Assay Detail
Binding
CHEMBL619914
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In vitro inhibitory activity against RBL-1 5-LO
47
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | RBL-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Hydroxamic acid inhibitors of 5-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 5.59 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65655 | — | — | 1 | 7.66 |
| CHEMBL154575 | — | — | 1 | 7.28 |
| CHEMBL65654 | — | — | 1 | 7.19 |
| CHEMBL155033 | — | — | 1 | 7.09 |
| CHEMBL154843 | — | — | 1 | 7.00 |
| CHEMBL63882 | — | — | 1 | 7.00 |
| CHEMBL155611 | — | — | 1 | 6.92 |
| CHEMBL156887 | — | — | 1 | 6.75 |
| CHEMBL304443 | — | — | 1 | 6.54 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 6.52 |
| CHEMBL154008 | — | — | 1 | 6.48 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | — | 1 | 6.40 |
| CHEMBL351338 | — | — | 1 | 6.33 |
| CHEMBL351785 | — | — | 1 | 6.30 |
| CHEMBL155443 | — | — | 1 | 6.02 |
| CHEMBL302754 | — | — | 1 | 5.89 |
| CHEMBL274642 | BW-755C | — | 1 | 5.89 |
| CHEMBL154827 | — | — | 1 | 5.70 |
| CHEMBL7660 | PHENIDONE | — | 1 | 5.68 |
| CHEMBL433690 | — | — | 1 | 5.66 |
| CHEMBL155522 | — | — | 1 | 5.54 |
| CHEMBL154585 | — | — | 1 | 5.39 |
| CHEMBL154517 | — | — | 1 | 5.22 |
| CHEMBL155236 | — | — | 1 | 5.19 |
| CHEMBL154899 | — | — | 1 | 5.15 |
| CHEMBL594621 | ICOMUCRET | 2.0 | 1 | 5.14 |
| CHEMBL154887 | — | — | 1 | 5.09 |
| CHEMBL154998 | — | — | 1 | 5.01 |
| CHEMBL154574 | — | — | 1 | 4.92 |
| CHEMBL351337 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65655 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL154575 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL65654 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL155033 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL154843 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL63882 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL155611 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL156887 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL304443 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL50 | QUERCETIN | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL154008 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL351338 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL351785 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL155443 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL302754 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL274642 | BW-755C | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL154827 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL7660 | PHENIDONE | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL433690 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL155522 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL154585 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL154517 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL155236 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL154899 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL594621 | ICOMUCRET | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL154887 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL154998 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL154574 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL351337 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL156672 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL155287 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL346935 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL155132 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL155319 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL154630 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL55895 | PHENYLBUTYRYLHYDROXAMIC ACID | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL152346 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL115468 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL154200 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL156835 | — | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL154302 | — | IC50 | = | 65000.0 | nM | 4.19 |
| CHEMBL152162 | — | IC50 | = | 87000.0 | nM | 4.06 |
| CHEMBL158240 | — | IC50 | = | 190000.0 | nM | - |
| CHEMBL155579 | — | IC50 | > | 400000.0 | nM | - |
| CHEMBL152665 | PHENYLACETOHYDROXAMIC ACID | IC50 | = | 300000.0 | nM | - |
| CHEMBL16300 | BENZOHYDROXAMATE | IC50 | = | 110000.0 | nM | - |