Assay Detail
Binding
CHEMBL619919
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its inhibitory activity against 5-lipoxygenase in rat.
9
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Development of L-689,065 - the prototype of a new class of potent 5-lipoxygenase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.80 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL295761 | — | — | 3 | 7.40 |
| CHEMBL93 | ZILEUTON | 4.0 | 1 | 6.70 |
| CHEMBL50170 | — | — | 1 | 6.52 |
| CHEMBL297661 | — | — | 1 | 6.16 |
| CHEMBL16596 | QUIFLAPON | 2.0 | 1 | - |
| CHEMBL31540 | — | — | 1 | - |
| CHEMBL47539 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL295761 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL295761 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL295761 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL93 | ZILEUTON | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL50170 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL297661 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL16596 | QUIFLAPON | IC50 | > | 2000.0 | nM | - |
| CHEMBL31540 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL47539 | — | IC50 | > | 8000.0 | nM | - |