Assay Detail
Binding
CHEMBL619920
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for the inhibition of 5-lipoxygenase (5-Lpo) in rat whole blood.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Blood |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
(Methoxyalkyl)thiazoles: a new series of potent, selective, and orally active 5-lipoxygenase inhibitors displaying high enantioselectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.54 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423835 | ZM-211965 | — | 1 | 6.30 |
| CHEMBL70191 | — | — | 1 | 6.10 |
| CHEMBL304320 | — | — | 1 | 5.22 |
| CHEMBL73720 | — | — | 1 | 4.52 |
| CHEMBL71332 | — | — | 1 | - |
| CHEMBL448162 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423835 | ZM-211965 | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL70191 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL304320 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL73720 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL71332 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL448162 | — | IC50 | > | 30000.0 | nM | - |