Assay Detail
Binding
CHEMBL619924
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In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined
57
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | RBL-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
3,4-Dihydroxychalcones as potent 5-lipoxygenase and cyclooxygenase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 57 | 7.20 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL126838 | — | — | 1 | 8.62 |
| CHEMBL125415 | — | — | 1 | 8.42 |
| CHEMBL341135 | — | — | 1 | 8.40 |
| CHEMBL129590 | — | — | 1 | 8.40 |
| CHEMBL126669 | — | — | 1 | 8.38 |
| CHEMBL128000 | BUTEIN | — | 1 | 8.34 |
| CHEMBL262892 | — | — | 1 | 8.33 |
| CHEMBL338199 | — | — | 1 | 8.28 |
| CHEMBL126894 | — | — | 1 | 8.19 |
| CHEMBL85000 | — | — | 1 | 8.16 |
| CHEMBL340783 | — | — | 1 | 8.11 |
| CHEMBL127593 | — | — | 1 | 8.07 |
| CHEMBL129160 | — | — | 1 | 8.05 |
| CHEMBL339788 | — | — | 1 | 8.01 |
| CHEMBL129523 | — | — | 1 | 8.00 |
| CHEMBL340911 | — | — | 1 | 7.96 |
| CHEMBL126252 | — | — | 1 | 7.85 |
| CHEMBL340244 | CALYTHROPSIN | — | 1 | 7.82 |
| CHEMBL127064 | — | — | 1 | 7.80 |
| CHEMBL126617 | — | — | 1 | 7.80 |
| CHEMBL126499 | — | — | 1 | 7.77 |
| CHEMBL129765 | — | — | 1 | 7.75 |
| CHEMBL126940 | — | — | 1 | 7.70 |
| CHEMBL129644 | — | — | 1 | 7.66 |
| CHEMBL339029 | — | — | 1 | 7.64 |
| CHEMBL339587 | — | — | 1 | 7.64 |
| CHEMBL125633 | — | — | 1 | 7.62 |
| CHEMBL125854 | — | — | 1 | 7.57 |
| CHEMBL126597 | — | — | 1 | 7.57 |
| CHEMBL340140 | — | — | 1 | 7.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL126838 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL125415 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL129590 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL341135 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL126669 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL128000 | BUTEIN | IC50 | = | 4.6 | nM | 8.34 |
| CHEMBL262892 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL338199 | — | IC50 | = | 5.3 | nM | 8.28 |
| CHEMBL126894 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL85000 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL340783 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL127593 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL129160 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL339788 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL129523 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL340911 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL126252 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL340244 | CALYTHROPSIN | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL127064 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL126617 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL126499 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL129765 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL126940 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL129644 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL339587 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL339029 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL125633 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL125854 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL126597 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL340140 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL126631 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL128990 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL126621 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL129510 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL126774 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL125800 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL340418 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL128012 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL127409 | 3,4,2',4',6'-PENTAHYDROXYCHALCONE | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL50 | QUERCETIN | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL338169 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL126647 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL130239 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL128605 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL7660 | PHENIDONE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL126657 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL130639 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL130640 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL129795 | ISOLIQUIRITIGENIN | IC50 | = | 35000.0 | nM | 4.46 |