Assay Detail
Binding
CHEMBL619926
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In vitro inhibition of 5-lipoxygenase from RBL-1 cells
35
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | RBL-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure-activity analysis of a class of orally active hydroxamic acid inhibitors of leukotriene biosynthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 6.22 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58810 | — | — | 1 | 6.72 |
| CHEMBL418304 | — | — | 2 | 6.55 |
| CHEMBL61360 | — | — | 1 | 6.54 |
| CHEMBL58077 | — | — | 1 | 6.50 |
| CHEMBL293413 | — | — | 1 | 6.48 |
| CHEMBL303074 | — | — | 1 | 6.44 |
| CHEMBL62209 | — | — | 1 | 6.43 |
| CHEMBL59419 | — | — | 1 | 6.42 |
| CHEMBL58866 | — | — | 1 | 6.41 |
| CHEMBL59634 | — | — | 1 | 6.40 |
| CHEMBL61638 | — | — | 1 | 6.39 |
| CHEMBL58049 | — | — | 1 | 6.34 |
| CHEMBL61608 | — | — | 1 | 6.34 |
| CHEMBL59442 | — | — | 1 | 6.33 |
| CHEMBL62114 | — | — | 1 | 6.30 |
| CHEMBL58286 | — | — | 1 | 6.27 |
| CHEMBL60231 | — | — | 1 | 6.24 |
| CHEMBL59334 | — | — | 1 | 6.21 |
| CHEMBL59833 | — | — | 1 | 6.21 |
| CHEMBL58233 | — | — | 1 | 6.19 |
| CHEMBL300346 | — | — | 1 | 6.16 |
| CHEMBL61642 | — | — | 1 | 6.13 |
| CHEMBL294725 | — | — | 1 | 6.12 |
| CHEMBL61584 | — | — | 1 | 6.12 |
| CHEMBL59250 | — | — | 2 | 6.11 |
| CHEMBL59841 | — | — | 1 | 6.11 |
| CHEMBL61765 | — | — | 1 | 6.06 |
| CHEMBL58462 | — | — | 1 | 6.03 |
| CHEMBL58212 | — | — | 1 | 5.96 |
| CHEMBL61719 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58810 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL418304 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL61360 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL58077 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL293413 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL303074 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL62209 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL418304 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL59419 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL58866 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL59634 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL61638 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL58049 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL61608 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL59442 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL62114 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL58286 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL60231 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL59833 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL59334 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL58233 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL300346 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL61642 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL61584 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL294725 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL59841 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL59250 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL59250 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL61765 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL58462 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL58212 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL61719 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL441246 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL61862 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL417392 | — | IC50 | = | 4900.0 | nM | 5.31 |