Assay Detail
Binding
CHEMBL619927
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of 5-lipoxygenase in RBL-1 cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | RBL-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Orally active hydroxamic acid inhibitors of leukotriene biosynthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.33 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69110 | — | — | 1 | 6.55 |
| CHEMBL65430 | — | — | 1 | 6.54 |
| CHEMBL418304 | — | — | 1 | 6.43 |
| CHEMBL444271 | — | — | 1 | 6.38 |
| CHEMBL146487 | — | — | 1 | 6.27 |
| CHEMBL146477 | — | — | 1 | 6.23 |
| CHEMBL303033 | — | — | 1 | 6.11 |
| CHEMBL59250 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69110 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL65430 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL418304 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL444271 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL146487 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL146477 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL303033 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL59250 | — | IC50 | = | 790.0 | nM | 6.10 |