Assay Detail
Binding
CHEMBL619929
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In vitro inhibition of RBL-1 5-lipoxygenase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | RBL-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel 1H-benzimidazol-4-ols with potent 5-lipoxygenase inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.49 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | — | 1 | 6.85 |
| CHEMBL304818 | DOCEBENONE | 2.0 | 1 | 5.70 |
| CHEMBL306680 | — | — | 1 | 4.70 |
| CHEMBL68893 | — | — | 1 | 4.70 |
| CHEMBL71427 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52 | NORDIHYDROGUAIARETIC ACID | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL304818 | DOCEBENONE | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL306680 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL68893 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL71427 | — | IC50 | ~ | 10000.0 | nM | - |