Assay Detail
Binding
CHEMBL619950
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In vitro inhibitory activity against 5-lipoxygenase from rat basophilic leukemia cells.
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and 5-lipoxygenase inhibitory activity of 5-hydroperoxy-6,8,11,14-eicosatetraenoic acid analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 4.93 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL557132 | — | — | 1 | 6.72 |
| CHEMBL274642 | BW-755C | — | 1 | 5.89 |
| CHEMBL18178 | — | — | 1 | 5.85 |
| CHEMBL18129 | — | — | 1 | 5.68 |
| CHEMBL7660 | PHENIDONE | — | 1 | 5.68 |
| CHEMBL277123 | — | — | 1 | 5.66 |
| CHEMBL17757 | — | — | 1 | 5.55 |
| CHEMBL18201 | — | — | 1 | 5.16 |
| CHEMBL18221 | — | — | 1 | 5.14 |
| CHEMBL18117 | — | — | 1 | 5.12 |
| CHEMBL429224 | — | — | 1 | 5.10 |
| CHEMBL17922 | — | — | 1 | 5.00 |
| CHEMBL18054 | — | — | 1 | 4.96 |
| CHEMBL18379 | — | — | 1 | 4.96 |
| CHEMBL18028 | 5-OXO-ETE | — | 1 | 4.75 |
| CHEMBL17883 | — | — | 1 | 4.68 |
| CHEMBL18112 | — | — | 1 | 4.66 |
| CHEMBL263073 | — | — | 1 | 4.60 |
| CHEMBL18584 | — | — | 1 | 4.60 |
| CHEMBL276929 | — | — | 1 | 4.57 |
| CHEMBL17775 | — | — | 1 | 4.54 |
| CHEMBL418364 | — | — | 1 | 4.44 |
| CHEMBL277539 | — | — | 1 | 4.26 |
| CHEMBL17983 | — | — | 1 | 4.23 |
| CHEMBL275848 | — | — | 1 | 4.17 |
| CHEMBL17695 | — | — | 1 | 4.11 |
| CHEMBL18239 | — | — | 1 | 4.02 |
| CHEMBL18435 | — | — | 1 | 4.01 |
| CHEMBL8747 | REV-5901 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL557132 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL274642 | BW-755C | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL18178 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL18129 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL7660 | PHENIDONE | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL277123 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL17757 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL18201 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL18221 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL18117 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL429224 | — | IC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL17922 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL18054 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL18379 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL18028 | 5-OXO-ETE | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL17883 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL18112 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL263073 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL18584 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL276929 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL17775 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL418364 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL277539 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL17983 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL275848 | — | IC50 | = | 68000.0 | nM | 4.17 |
| CHEMBL17695 | — | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL18239 | — | IC50 | = | 96000.0 | nM | 4.02 |
| CHEMBL18435 | — | IC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL8747 | REV-5901 | IC50 | > | 45000.0 | nM | - |