Assay Detail
Binding
CHEMBL619998
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for its inhibitory activity against arachidonic acid in rat 5-lipoxygenase.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Development of 2,3-dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol (L-670,630) as a potent and orally active inhibitor of 5-lipoxygenase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.39 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL24178 | — | — | 1 | 8.10 |
| CHEMBL279934 | — | — | 1 | 7.77 |
| CHEMBL282530 | — | — | 1 | 7.64 |
| CHEMBL416197 | — | — | 1 | 7.60 |
| CHEMBL25262 | — | — | 1 | 7.40 |
| CHEMBL28093 | — | — | 1 | 7.36 |
| CHEMBL24633 | — | — | 1 | 7.36 |
| CHEMBL278861 | — | — | 1 | 7.35 |
| CHEMBL25515 | — | — | 1 | 7.35 |
| CHEMBL25666 | — | — | 1 | 7.32 |
| CHEMBL282904 | — | — | 1 | 7.30 |
| CHEMBL278817 | — | — | 1 | 7.29 |
| CHEMBL25194 | — | — | 1 | 7.28 |
| CHEMBL25530 | — | — | 1 | 7.28 |
| CHEMBL24632 | — | — | 1 | 7.04 |
| CHEMBL280192 | — | — | 1 | 6.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL24178 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL279934 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL282530 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL416197 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL25262 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL28093 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL24633 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL278861 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL25515 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL25666 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL282904 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL278817 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL25194 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL25530 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL24632 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL280192 | — | IC50 | = | 164.0 | nM | 6.79 |