Assay Detail
Functional
CHEMBL620367
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Tested in vitro for growth inhibitory activity against 833K (human teratorcarcinoma) cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | 833K |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
7-Silylcamptothecins (silatecans): A new family of camptothecin antitumor agents
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 8.02 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL321859 | — | — | 1 | 9.85 |
| CHEMBL420481 | — | — | 1 | 9.04 |
| CHEMBL321208 | — | — | 1 | 8.92 |
| CHEMBL109032 | — | — | 1 | 8.68 |
| CHEMBL107934 | — | — | 1 | 8.54 |
| CHEMBL322789 | — | — | 1 | 8.25 |
| CHEMBL107547 | — | — | 1 | 8.24 |
| CHEMBL108601 | — | — | 1 | 8.15 |
| CHEMBL322959 | — | — | 1 | 8.13 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.00 |
| CHEMBL322525 | — | — | 1 | 7.82 |
| CHEMBL320772 | — | — | 1 | 7.08 |
| CHEMBL324430 | — | — | 1 | 6.67 |
| CHEMBL441077 | — | — | 1 | 6.61 |
| CHEMBL108809 | — | — | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL321859 | — | IC50 | = | 0.14 | nM | 9.85 |
| CHEMBL420481 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL321208 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL109032 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL107934 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL322789 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL107547 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL108601 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL322959 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL322525 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL320772 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL324430 | — | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL441077 | — | IC50 | = | 243.0 | nM | 6.61 |
| CHEMBL108809 | — | IC50 | = | 487.0 | nM | 6.31 |