Assay Detail
Functional
CHEMBL620381
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested in vitro for anticancer activity against 9L cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | 9L |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of 2',3'-didehydro-2',3'- dideoxy-5-fluorocytidine (D4FC) analogues: discovery of carbocyclic nucleoside triphosphates with potent inhibitory activity against HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.09 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL123292 | CYCLOHEXIMIDE | 2.0 | 1 | 6.70 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 6.00 |
| CHEMBL355426 | — | — | 1 | 5.92 |
| CHEMBL169267 | — | — | 1 | 5.72 |
| CHEMBL2368321 | — | — | 1 | - |
| CHEMBL171286 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL123292 | CYCLOHEXIMIDE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL355426 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL169267 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2368321 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL171286 | — | IC50 | > | 100000.0 | nM | - |