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Compound Detail

CHEMBL2368321

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Nc1nc(=O)n([C@@H]2C=C[C@@H](CO)O2)cc1F

Basic Information

ChEMBL ID CHEMBL2368321
Phase Preclinical
Structure Type MOL
InChI Key HSBKFSPNDWWPSL-FSPLSTOPSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
11
Publications
0
Known Names

Molecular Properties

227.2
MW (Da)
-0.59
ALogP
6
HBA
2
HBD
90.4
PSA (Ų)
0.66
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C9H10FN3O3
MW 227.19
Aromatic Rings 1
Heavy Atoms 16
NP-Likeness 0.69

Activity Summary

EC50 1 meas. best 4.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Human immunodeficiency virus 1
CHEMBL378
EC50 4.7 4.7 20000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Human immunodeficiency virus 1 EC50 = 20000.0 nM 4.7 Tested in vitro for anti HIV-1 activity against PBM cells 10072683

Literature References

Data from ChEMBL 36 via Core Engine