Assay Detail
Functional
CHEMBL757789
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Tested in vitro for anti HIV-1 activity against PBM cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | PBM |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and biological evaluation of 2',3'-didehydro-2',3'- dideoxy-5-fluorocytidine (D4FC) analogues: discovery of carbocyclic nucleoside triphosphates with potent inhibitory activity against HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 6.32 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.70 |
| CHEMBL38700 | ELVUCITABINE | 2.0 | 1 | 7.47 |
| CHEMBL109831 | DEXELVUCITABINE | 2.0 | 1 | 7.34 |
| CHEMBL354904 | — | — | 1 | 7.25 |
| CHEMBL171878 | — | — | 1 | 6.89 |
| CHEMBL171286 | — | — | 1 | 6.82 |
| CHEMBL169267 | — | — | 1 | 6.58 |
| CHEMBL355081 | — | — | 1 | 6.00 |
| CHEMBL2368322 | — | — | 1 | 5.12 |
| CHEMBL355426 | — | — | 1 | 5.10 |
| CHEMBL171444 | — | — | 1 | 5.09 |
| CHEMBL168395 | — | — | 1 | 5.05 |
| CHEMBL2368321 | — | — | 1 | 4.70 |
| CHEMBL366529 | — | — | 1 | - |
| CHEMBL169434 | — | — | 1 | - |
| CHEMBL169277 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL38700 | ELVUCITABINE | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL109831 | DEXELVUCITABINE | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL354904 | — | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL171878 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL171286 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL169267 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL355081 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2368322 | — | EC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL355426 | — | EC50 | = | 7900.0 | nM | 5.10 |
| CHEMBL171444 | — | EC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL168395 | — | EC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL2368321 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL366529 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL169434 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL169277 | — | EC50 | > | 100000.0 | nM | - |