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Compound Detail

CHEMBL169277

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CCCNc1nc(=O)n([C@H]2C=C[C@@H](CO)O2)cc1F

Basic Information

ChEMBL ID CHEMBL169277
Phase Preclinical
Structure Type MOL
InChI Key HOWSBHNLKXCPNO-WCBMZHEXSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
11
Publications
0
Known Names

Molecular Properties

269.3
MW (Da)
0.65
ALogP
6
HBA
2
HBD
76.4
PSA (Ų)
0.77
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C12H16FN3O3
MW 269.28
Aromatic Rings 1
Heavy Atoms 19
NP-Likeness 0.20

Activity Summary

IC50 1 meas. best 4.46

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
ADMET
CHEMBL612558
IC50 4.46 4.46 34700.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
ADMET IC50 = 34700.0 nM 4.46 Tested in vitro for cytotoxicity against PBM cells 10072683

Literature References

Data from ChEMBL 36 via Core Engine