Assay Detail
Functional
CHEMBL757069
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Tested in vitro for cytotoxicity against PBM cells
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBM |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 2',3'-didehydro-2',3'- dideoxy-5-fluorocytidine (D4FC) analogues: discovery of carbocyclic nucleoside triphosphates with potent inhibitory activity against HIV-1 reverse transcriptase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.76 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL123292 | CYCLOHEXIMIDE | 2.0 | 1 | 5.68 |
| CHEMBL169267 | — | — | 1 | 5.64 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.30 |
| CHEMBL38700 | ELVUCITABINE | 2.0 | 1 | 4.89 |
| CHEMBL355426 | — | — | 1 | 4.49 |
| CHEMBL169277 | — | — | 1 | 4.46 |
| CHEMBL2368322 | — | — | 1 | 4.32 |
| CHEMBL169434 | — | — | 1 | 4.04 |
| CHEMBL366529 | — | — | 1 | 4.01 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | - |
| CHEMBL2368321 | — | — | 1 | - |
| CHEMBL168395 | — | — | 1 | - |
| CHEMBL354904 | — | — | 1 | - |
| CHEMBL355081 | — | — | 1 | - |
| CHEMBL171444 | — | — | 1 | - |
| CHEMBL171286 | — | — | 1 | - |
| CHEMBL171878 | — | — | 1 | - |
| CHEMBL109831 | DEXELVUCITABINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL123292 | CYCLOHEXIMIDE | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL169267 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL38700 | ELVUCITABINE | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL355426 | — | IC50 | = | 32200.0 | nM | 4.49 |
| CHEMBL169277 | — | IC50 | = | 34700.0 | nM | 4.46 |
| CHEMBL2368322 | — | IC50 | = | 47400.0 | nM | 4.32 |
| CHEMBL169434 | — | IC50 | = | 91600.0 | nM | 4.04 |
| CHEMBL366529 | — | IC50 | = | 98300.0 | nM | 4.01 |
| CHEMBL129 | ZIDOVUDINE | IC50 | > | 100000.0 | nM | - |
| CHEMBL2368321 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL168395 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL354904 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL355081 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL171444 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL171286 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL171878 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL109831 | DEXELVUCITABINE | IC50 | > | 100000.0 | nM | - |