Assay Detail
Functional
CHEMBL620387
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to induce human IL-6 assay in A549 lung carcinoma cell line.
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel N-arylpyrazolo[3,2-c]-based ligands for the glucocorticoid receptor: receptor binding and in vivo activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 8.12 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310570 | — | — | 1 | 9.00 |
| CHEMBL81111 | — | — | 1 | 8.72 |
| CHEMBL311662 | — | — | 1 | 8.66 |
| CHEMBL310365 | — | — | 1 | 8.57 |
| CHEMBL81591 | — | — | 1 | 8.54 |
| CHEMBL312041 | — | — | 1 | 8.52 |
| CHEMBL82546 | — | — | 1 | 8.49 |
| CHEMBL79335 | — | — | 1 | 8.36 |
| CHEMBL131 | PREDNISOLONE | 4.0 | 1 | 8.35 |
| CHEMBL312399 | — | — | 1 | 8.07 |
| CHEMBL309243 | — | — | 1 | 8.03 |
| CHEMBL79807 | — | — | 1 | 8.01 |
| CHEMBL83110 | — | — | 1 | 7.99 |
| CHEMBL419479 | — | — | 1 | 7.94 |
| CHEMBL310420 | — | — | 1 | 7.86 |
| CHEMBL420767 | — | — | 1 | 7.84 |
| CHEMBL313062 | — | — | 1 | 7.84 |
| CHEMBL311034 | — | — | 1 | 7.81 |
| CHEMBL81397 | — | — | 1 | 7.71 |
| CHEMBL440877 | — | — | 1 | 7.62 |
| CHEMBL313400 | — | — | 1 | 7.50 |
| CHEMBL309909 | — | — | 1 | 7.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310570 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL81111 | — | EC50 | = | 1.9 | nM | 8.72 |
| CHEMBL311662 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL310365 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL81591 | — | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL312041 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL82546 | — | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL79335 | — | EC50 | = | 4.4 | nM | 8.36 |
| CHEMBL131 | PREDNISOLONE | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL312399 | — | EC50 | = | 8.6 | nM | 8.07 |
| CHEMBL309243 | — | EC50 | = | 9.3 | nM | 8.03 |
| CHEMBL79807 | — | EC50 | = | 9.7 | nM | 8.01 |
| CHEMBL83110 | — | EC50 | = | 10.2 | nM | 7.99 |
| CHEMBL419479 | — | EC50 | = | 11.4 | nM | 7.94 |
| CHEMBL310420 | — | EC50 | = | 13.9 | nM | 7.86 |
| CHEMBL420767 | — | EC50 | = | 14.3 | nM | 7.84 |
| CHEMBL313062 | — | EC50 | = | 14.4 | nM | 7.84 |
| CHEMBL311034 | — | EC50 | = | 15.5 | nM | 7.81 |
| CHEMBL81397 | — | EC50 | = | 19.5 | nM | 7.71 |
| CHEMBL440877 | — | EC50 | = | 24.2 | nM | 7.62 |
| CHEMBL313400 | — | EC50 | = | 31.3 | nM | 7.50 |
| CHEMBL309909 | — | EC50 | = | 54.2 | nM | 7.27 |