Assay Detail
Functional
CHEMBL620436
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Cytotoxicity against Beta- tubulin mutant expressing A9-PTX10 cell line of humans was tested
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A9-PTX10 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.61 | 7.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL329817 | — | — | 1 | 7.86 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 7.86 |
| CHEMBL300734 | — | — | 1 | 7.11 |
| CHEMBL95224 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL329817 | — | IC50 | = | 13.8 | nM | 7.86 |
| CHEMBL107 | COLCHICINE | IC50 | = | 13.8 | nM | 7.86 |
| CHEMBL300734 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL95224 | — | IC50 | > | 100.0 | nM | - |