Assay Detail
Functional
CHEMBL620515
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Tested for cytotoxicity against ADJ/PC6 plasmacytoma
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Plasma |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Effect of A-ring modifications on the DNA-binding behavior and cytotoxicity of pyrrolo[2,1-c][1,4]benzodiazepines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.04 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL17192 | — | — | 1 | 8.74 |
| CHEMBL293096 | — | — | 1 | 6.48 |
| CHEMBL54666 | — | — | 1 | 6.43 |
| CHEMBL433491 | — | — | 1 | 5.89 |
| CHEMBL418651 | — | — | 1 | 5.72 |
| CHEMBL292689 | — | — | 1 | 5.64 |
| CHEMBL291815 | — | — | 1 | 5.57 |
| CHEMBL293119 | — | — | 1 | 5.47 |
| CHEMBL416315 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL17192 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL293096 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL54666 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL433491 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL418651 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL292689 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL291815 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL293119 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL416315 | — | IC50 | = | 38000.0 | nM | 4.42 |