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Assay Detail

CHEMBL620582

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]-BRC 36694 from 5-hydroxytryptamine 3 receptor in NG108-15 cells
16
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Cell Type NG108-15
Confidence 4 — Cell-line / Tissue
Curated By Expert

Target

Serotonin 3 receptor (5HT3) (CHEMBL2111333)
Type PROTEIN FAMILY
Organism Mus musculus

Publication

3-amino-3,4-dihydro-2H-1-benzopyran derivatives as 5-HT1A receptor ligands and potential anxiolytic agents. 2. Synthesis and quantitative structure-activity relationship studies of spiro[pyrrolidine- and piperidine-2,3'(2'H)-benzopyrans]
Comoy C, Marot C, Podona T, Baudin ML, Morin-Allory L, Guillaumet G, Pfeiffer B, Caignard DH, Renard P, Rettori MC, Adam G, Guardiola-Lemaitre B.
J Med Chem (1996) 39 : 4285 -4298
PubMed 8863806 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 4.87 5.45

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL422453 1 5.45
CHEMBL133375 1 5.40
CHEMBL135489 1 5.10
CHEMBL137643 1 4.99
CHEMBL11265 3 4.97
CHEMBL135952 1 4.90
CHEMBL135490 1 4.84
CHEMBL137478 1 4.83
CHEMBL422283 1 4.38
CHEMBL334498 1 4.18
CHEMBL132970 1 -
CHEMBL137486 1 -
CHEMBL135335 1 -
CHEMBL137642 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL422453 IC50 = 3590.0 nM 5.45
CHEMBL133375 IC50 = 3970.0 nM 5.40
CHEMBL135489 IC50 = 7930.0 nM 5.10
CHEMBL137643 IC50 = 10200.0 nM 4.99
CHEMBL11265 IC50 = 10600.0 nM 4.97
CHEMBL11265 IC50 = 12100.0 nM 4.92
CHEMBL135952 IC50 = 12500.0 nM 4.90
CHEMBL135490 IC50 = 14500.0 nM 4.84
CHEMBL137478 IC50 = 14900.0 nM 4.83
CHEMBL11265 IC50 = 30700.0 nM 4.51
CHEMBL422283 IC50 = 41400.0 nM 4.38
CHEMBL334498 IC50 = 66500.0 nM 4.18
CHEMBL132970 IC50 > 1000000.0 nM -
CHEMBL137486 IC50 = 118000.0 nM -
CHEMBL135335 IC50 > 1000000.0 nM -
CHEMBL137642 IC50 > 1000000.0 nM -