Assay Detail
Binding
CHEMBL620587
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The binding affinity was measured for 5-hydroxytryptamine 3 receptor on NG 108-15 cell line of mouse neuroblastoma-glioma cells in presence of [3H]5 radioligand (in vitro)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | NG 108-15 |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis, in vitro binding profile, and central nervous system penetrability of the highly potent 5-HT3 receptor antagonist [3H]-4-(2-methoxyphenyl)-2-[4(5)-methyl-5(4)-imidazolylmethyl]thiazole.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 7.45 | 8.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18041 | ZACOPRIDE | 2.0 | 1 | 8.88 |
| CHEMBL56564 | TROPISETRON | 3.0 | 1 | 8.42 |
| CHEMBL18772 | QUIPAZINE | 2.0 | 1 | 8.06 |
| CHEMBL46 | ONDANSETRON | 4.0 | 1 | 7.92 |
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | 6.60 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 6.44 |
| CHEMBL266591 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18041 | ZACOPRIDE | Ki | = | 1.32 | nM | 8.88 |
| CHEMBL56564 | TROPISETRON | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL18772 | QUIPAZINE | Ki | = | 8.67 | nM | 8.06 |
| CHEMBL46 | ONDANSETRON | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL6437 | MIANSERIN | Ki | = | 252.0 | nM | 6.60 |
| CHEMBL39 | SEROTONIN | Ki | = | 361.0 | nM | 6.44 |
| CHEMBL266591 | — | Ki | = | 1430.0 | nM | 5.84 |