Assay Detail
Binding
CHEMBL620622
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Binding affinity towards rat 5-hydroxytryptamine 3 receptor was evaluated
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serotonin 3 (5-HT3) receptor (CHEMBL2094116) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Synthesis and pharmacology of isoquinuclidine derivatives as 5-HT(3) ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 9.01 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL56900 | LERISETRON | 3.0 | 1 | 9.21 |
| CHEMBL56564 | TROPISETRON | 3.0 | 1 | 8.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL56900 | LERISETRON | Ki | = | 0.62 | nM | 9.21 |
| CHEMBL56564 | TROPISETRON | Ki | = | 1.55 | nM | 8.81 |