Assay Detail
Binding
CHEMBL620623
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Binding affinity against 5-hydroxytryptamine 3 receptor using [3H]BRL-43694 in rat posterior cortex
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cortex |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serotonin 3 (5-HT3) receptor (CHEMBL2094116) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Design of a potent 5-HT4 receptor agonist with nanomolar affinity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.61 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18041 | ZACOPRIDE | 2.0 | 1 | 9.15 |
| CHEMBL288199 | — | — | 1 | 9.15 |
| CHEMBL33676 | — | — | 1 | 8.49 |
| CHEMBL41769 | — | — | 1 | 8.44 |
| CHEMBL34224 | — | — | 1 | 7.14 |
| CHEMBL33732 | — | — | 1 | 6.93 |
| CHEMBL287045 | — | — | 1 | 6.69 |
| CHEMBL86 | METOCLOPRAMIDE | 4.0 | 1 | 6.35 |
| CHEMBL286136 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18041 | ZACOPRIDE | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL288199 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL33676 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL41769 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL34224 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL33732 | — | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL287045 | — | Ki | = | 205.0 | nM | 6.69 |
| CHEMBL86 | METOCLOPRAMIDE | Ki | = | 443.0 | nM | 6.35 |
| CHEMBL286136 | — | Ki | = | 782.0 | nM | 6.11 |