Assay Detail
Binding
CHEMBL620624
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Binding affinity against 5-hydroxytryptamine 3 receptor using [3H]BRL-43694 as radioligand in rat posterior cortex
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cortex |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serotonin 3 (5-HT3) receptor (CHEMBL2094116) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Synthesis and pharmacological activity of a macrocyclic benzamide
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.73 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28992 | — | — | 1 | 9.70 |
| CHEMBL301039 | — | — | 2 | 9.10 |
| CHEMBL116913 | — | — | 1 | 7.27 |
| CHEMBL164425 | — | — | 1 | 6.57 |
| CHEMBL86 | METOCLOPRAMIDE | 4.0 | 1 | 6.35 |
| CHEMBL164169 | — | — | 1 | - |
| CHEMBL325109 | CLEBOPRIDE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28992 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL301039 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL301039 | — | Ki | = | 41.8 | nM | 7.38 |
| CHEMBL116913 | — | Ki | = | 53.2 | nM | 7.27 |
| CHEMBL164425 | — | Ki | = | 267.0 | nM | 6.57 |
| CHEMBL86 | METOCLOPRAMIDE | Ki | = | 443.0 | nM | 6.35 |
| CHEMBL164169 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL325109 | CLEBOPRIDE | Ki | > | 1000.0 | nM | - |