Assay Detail
Binding
CHEMBL620632
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Binding affinity for 5-hydroxytryptamine 3 receptor from rat cortex using [3H]BRL-43694 as radioligand
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serotonin 3 (5-HT3) receptor (CHEMBL2094116) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Novel, potent, and selective 5-HT3 receptor antagonists based on the arylpiperazine skeleton: synthesis, structure, biological activity, and comparative molecular field analysis studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 7.75 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18772 | QUIPAZINE | 2.0 | 1 | 8.92 |
| CHEMBL46 | ONDANSETRON | 4.0 | 1 | 8.92 |
| CHEMBL304193 | — | — | 1 | 8.80 |
| CHEMBL417706 | — | — | 1 | 8.46 |
| CHEMBL62589 | — | — | 1 | 8.42 |
| CHEMBL62636 | — | — | 1 | 8.27 |
| CHEMBL64416 | — | — | 1 | 8.10 |
| CHEMBL41462 | — | — | 1 | 8.02 |
| CHEMBL64879 | — | — | 1 | 7.94 |
| CHEMBL59871 | — | — | 1 | 7.91 |
| CHEMBL293866 | — | — | 1 | 7.90 |
| CHEMBL293703 | — | — | 1 | 7.84 |
| CHEMBL292260 | — | — | 1 | 7.79 |
| CHEMBL430566 | — | — | 1 | 7.49 |
| CHEMBL291771 | — | — | 1 | 7.38 |
| CHEMBL304016 | — | — | 1 | 7.34 |
| CHEMBL64146 | — | — | 1 | 7.28 |
| CHEMBL62449 | — | — | 1 | 7.27 |
| CHEMBL303999 | — | — | 1 | 7.18 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 7.18 |
| CHEMBL61007 | — | — | 1 | 6.89 |
| CHEMBL293218 | — | — | 1 | 6.66 |
| CHEMBL64145 | — | — | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18772 | QUIPAZINE | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL46 | ONDANSETRON | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL304193 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL417706 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL62589 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL62636 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL64416 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL41462 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL64879 | — | Ki | = | 11.5 | nM | 7.94 |
| CHEMBL59871 | — | Ki | = | 12.3 | nM | 7.91 |
| CHEMBL293866 | — | Ki | = | 12.5 | nM | 7.90 |
| CHEMBL293703 | — | Ki | = | 14.4 | nM | 7.84 |
| CHEMBL292260 | — | Ki | = | 16.4 | nM | 7.79 |
| CHEMBL430566 | — | Ki | = | 32.5 | nM | 7.49 |
| CHEMBL291771 | — | Ki | = | 41.6 | nM | 7.38 |
| CHEMBL304016 | — | Ki | = | 45.9 | nM | 7.34 |
| CHEMBL64146 | — | Ki | = | 52.2 | nM | 7.28 |
| CHEMBL62449 | — | Ki | = | 53.3 | nM | 7.27 |
| CHEMBL303999 | — | Ki | = | 66.5 | nM | 7.18 |
| CHEMBL39 | SEROTONIN | Ki | = | 66.0 | nM | 7.18 |
| CHEMBL61007 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL293218 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL64145 | — | Ki | = | 410.0 | nM | 6.39 |