Assay Detail
Binding
CHEMBL620654
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Inhibition of [3H]-Q-ICS 205-930 binding to rat cortex homogenate 5-hydroxytryptamine 3 receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serotonin 3 (5-HT3) receptor (CHEMBL2094116) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Synthesis and serotonergic activity of N,N-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine and analogues: potent agonists for 5-HT1D receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.52 | 5.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52912 | — | — | 1 | 5.90 |
| CHEMBL53485 | — | — | 1 | 5.90 |
| CHEMBL53349 | — | — | 1 | 5.80 |
| CHEMBL299213 | — | — | 1 | 5.60 |
| CHEMBL298544 | — | — | 1 | 5.60 |
| CHEMBL39243 | — | — | 1 | 5.60 |
| CHEMBL53764 | — | — | 1 | 5.50 |
| CHEMBL53467 | — | — | 1 | 5.50 |
| CHEMBL53128 | — | — | 1 | 5.30 |
| CHEMBL54265 | — | — | 1 | 5.00 |
| CHEMBL52264 | — | — | 1 | 5.00 |
| CHEMBL50834 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52912 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL53485 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL53349 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL299213 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL298544 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL39243 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL53764 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL53467 | — | IC50 | = | 3162.28 | nM | 5.50 |
| CHEMBL53128 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL54265 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL52264 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL50834 | — | IC50 | > | 10000.0 | nM | - |