Assay Detail
Binding
CHEMBL620723
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration that inhibits the binding of radioligand, [3H]-ICS 205930, to 5-hydroxytryptamine 3 receptor from rat cortex
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Serotonin 3 (5-HT3) receptor (CHEMBL2094116) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Synthesis of a new class of 2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic acid derivatives as highly potent 5-HT3 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 41 | 7.90 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL63742 | — | — | 1 | 9.05 |
| CHEMBL540017 | — | — | 1 | 8.81 |
| CHEMBL293239 | — | — | 1 | 8.77 |
| CHEMBL56564 | TROPISETRON | 3.0 | 1 | 8.77 |
| CHEMBL64986 | — | — | 1 | 8.68 |
| CHEMBL539262 | — | — | 1 | 8.66 |
| CHEMBL544755 | — | — | 1 | 8.64 |
| CHEMBL293468 | — | — | 1 | 8.43 |
| CHEMBL542869 | — | — | 1 | 8.10 |
| CHEMBL543340 | — | — | 1 | 7.92 |
| CHEMBL554389 | — | — | 1 | 7.79 |
| CHEMBL545449 | — | — | 1 | 7.75 |
| CHEMBL63891 | — | — | 1 | 7.70 |
| CHEMBL306003 | — | — | 1 | 7.67 |
| CHEMBL2107804 | BEMESETRON | 2.0 | 1 | 7.61 |
| CHEMBL541040 | — | — | 1 | 7.58 |
| CHEMBL63409 | — | — | 1 | 7.47 |
| CHEMBL539003 | — | — | 1 | 7.47 |
| CHEMBL552824 | — | — | 1 | 7.14 |
| CHEMBL65226 | — | — | 1 | 6.89 |
| CHEMBL555995 | — | — | 1 | 6.51 |
| CHEMBL418673 | — | — | 1 | 6.36 |
| CHEMBL63621 | — | — | 1 | - |
| CHEMBL67403 | — | — | 1 | - |
| CHEMBL542634 | — | — | 1 | - |
| CHEMBL552854 | — | — | 1 | - |
| CHEMBL539006 | — | — | 1 | - |
| CHEMBL555088 | — | — | 1 | - |
| CHEMBL539261 | — | — | 1 | - |
| CHEMBL538247 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL63742 | — | Ki | = | 0.89 | nM | 9.05 |
| CHEMBL540017 | — | Ki | = | 1.53 | nM | 8.81 |
| CHEMBL56564 | TROPISETRON | Ki | = | 1.71 | nM | 8.77 |
| CHEMBL293239 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL64986 | — | Ki | = | 2.07 | nM | 8.68 |
| CHEMBL539262 | — | Ki | = | 2.17 | nM | 8.66 |
| CHEMBL544755 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL293468 | — | Ki | = | 3.75 | nM | 8.43 |
| CHEMBL542869 | — | Ki | = | 7.94 | nM | 8.10 |
| CHEMBL543340 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL554389 | — | Ki | = | 16.3 | nM | 7.79 |
| CHEMBL545449 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL63891 | — | Ki | = | 20.2 | nM | 7.70 |
| CHEMBL306003 | — | Ki | = | 21.4 | nM | 7.67 |
| CHEMBL2107804 | BEMESETRON | Ki | = | 24.4 | nM | 7.61 |
| CHEMBL541040 | — | Ki | = | 26.2 | nM | 7.58 |
| CHEMBL63409 | — | Ki | = | 33.6 | nM | 7.47 |
| CHEMBL539003 | — | Ki | = | 33.9 | nM | 7.47 |
| CHEMBL552824 | — | Ki | = | 72.4 | nM | 7.14 |
| CHEMBL65226 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL555995 | — | Ki | = | 306.0 | nM | 6.51 |
| CHEMBL418673 | — | Ki | = | 436.0 | nM | 6.36 |
| CHEMBL554844 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL539005 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL540782 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL541283 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL68348 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL555791 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL553266 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL66972 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL554755 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL303463 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL304382 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL538247 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL539261 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL555088 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL539006 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL552854 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL542634 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL67403 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL63621 | — | Ki | > | 1000.0 | nM | - |