Assay Detail
Binding
CHEMBL620750
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Binding affinity towards rat 5-hydroxytryptamine 7 receptor
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 7.78 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1423 | PIMOZIDE | 4.0 | 1 | 9.30 |
| CHEMBL85 | RISPERIDONE | 4.0 | 1 | 8.85 |
| CHEMBL263881 | LYSERGIDE | 2.0 | 1 | 8.70 |
| CHEMBL93240 | METITEPINE | 2.0 | 1 | 8.40 |
| CHEMBL908 | CHLORPROTHIXENE | 4.0 | 1 | 8.25 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 8.20 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.00 |
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 8.00 |
| CHEMBL267777 | RITANSERIN | 2.0 | 1 | 7.82 |
| CHEMBL71 | CHLORPROMAZINE | 4.0 | 1 | 7.68 |
| CHEMBL95067 | DISULERGINE | 2.0 | 1 | 7.68 |
| CHEMBL831 | LOXAPINE | 4.0 | 1 | 7.37 |
| CHEMBL13816 | — | — | 1 | 7.22 |
| CHEMBL97518 | — | — | 1 | 7.10 |
| CHEMBL6437 | MIANSERIN | 4.0 | 1 | 7.00 |
| CHEMBL96055 | — | — | 1 | 6.98 |
| CHEMBL56 | 8-OH-DPAT | — | 1 | 6.82 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1423 | PIMOZIDE | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL85 | RISPERIDONE | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL263881 | LYSERGIDE | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL93240 | METITEPINE | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL908 | CHLORPROTHIXENE | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL42 | CLOZAPINE | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL39 | SEROTONIN | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL267930 | SPIPERONE | Ki | = | 9.9 | nM | 8.00 |
| CHEMBL267777 | RITANSERIN | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL71 | CHLORPROMAZINE | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL95067 | DISULERGINE | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL831 | LOXAPINE | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL13816 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL97518 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL6437 | MIANSERIN | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL96055 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL56 | 8-OH-DPAT | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 263.0 | nM | 6.58 |