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Assay Detail

CHEMBL620752

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Binding
Binding affinity to the rat 5-hydroxytryptamine 7 receptor
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 7 (CHEMBL3223)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Synthesis and structure-affinity relationships of 1-[omega-(4-aryl-1-piperazinyl)alkyl]-1-aryl ketones as 5-HT(7) receptor ligands.
Perrone R, Berardi F, Colabufo NA, Lacivita E, Leopoldo M, Tortorella V.
J Med Chem (2003) 46 : 646 -649
PubMed 12570387 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 24 7.48 9.29

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL18840 1 9.29
CHEMBL159022 1 9.05
CHEMBL160817 1 8.53
CHEMBL156089 1 8.24
CHEMBL160906 1 7.82
CHEMBL157081 1 7.79
CHEMBL160706 1 7.71
CHEMBL155861 1 7.62
CHEMBL158770 1 7.57
CHEMBL158850 1 7.55
CHEMBL347629 1 7.37
CHEMBL347837 1 7.36
CHEMBL160286 1 7.34
CHEMBL422008 1 7.28
CHEMBL160194 1 7.23
CHEMBL26135 1 7.07
CHEMBL156385 1 6.98
CHEMBL26677 1 6.96
CHEMBL158592 1 6.83
CHEMBL157362 1 6.42
CHEMBL157840 1 6.33
CHEMBL158332 1 6.17
CHEMBL155860 1 -
CHEMBL155916 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL18840 Ki = 0.51 nM 9.29
CHEMBL159022 Ki = 0.9 nM 9.05
CHEMBL160817 Ki = 2.93 nM 8.53
CHEMBL156089 Ki = 5.8 nM 8.24
CHEMBL160906 Ki = 15.0 nM 7.82
CHEMBL157081 Ki = 16.4 nM 7.79
CHEMBL160706 Ki = 19.5 nM 7.71
CHEMBL155861 Ki = 23.7 nM 7.62
CHEMBL158770 Ki = 26.8 nM 7.57
CHEMBL158850 Ki = 28.4 nM 7.55
CHEMBL347629 Ki = 43.0 nM 7.37
CHEMBL347837 Ki = 43.5 nM 7.36
CHEMBL160286 Ki = 46.0 nM 7.34
CHEMBL422008 Ki = 52.0 nM 7.28
CHEMBL160194 Ki = 59.1 nM 7.23
CHEMBL26135 Ki = 85.0 nM 7.07
CHEMBL156385 Ki = 105.0 nM 6.98
CHEMBL26677 Ki = 109.0 nM 6.96
CHEMBL158592 Ki = 148.0 nM 6.83
CHEMBL157362 Ki = 384.0 nM 6.42
CHEMBL157840 Ki = 462.0 nM 6.33
CHEMBL158332 Ki = 682.0 nM 6.17
CHEMBL155860 Ki > 1000.0 nM -
CHEMBL155916 Ki > 800.0 nM -