Assay Detail
Binding
CHEMBL620753
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Binding affinity against Rat 5-hydroxytryptamine 7 receptor using [3H]5-HT
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Derivatives of (R)-1,11-methyleneaporphine: synthesis, structure, and interactions with G-protein coupled receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.80 | 10.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18840 | — | — | 1 | 10.54 |
| CHEMBL282863 | — | — | 1 | 8.47 |
| CHEMBL27132 | — | — | 1 | 8.25 |
| CHEMBL284586 | — | — | 1 | 8.16 |
| CHEMBL26998 | — | — | 1 | 8.05 |
| CHEMBL27940 | — | — | 1 | 7.42 |
| CHEMBL281357 | — | — | 1 | 7.06 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 6.73 |
| CHEMBL22778 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18840 | — | Ki | = | 0.029 | nM | 10.54 |
| CHEMBL282863 | — | Ki | = | 3.36 | nM | 8.47 |
| CHEMBL27132 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL284586 | — | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL26998 | — | Ki | = | 8.81 | nM | 8.05 |
| CHEMBL27940 | — | Ki | = | 38.3 | nM | 7.42 |
| CHEMBL281357 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL53 | APOMORPHINE | Ki | = | 188.0 | nM | 6.73 |
| CHEMBL22778 | — | Ki | = | 3180.0 | nM | 5.50 |