Assay Detail
Binding
CHEMBL620768
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Binding affinity towards cloned rat 5-hydroxytryptamine 7 receptor was determined using [3H]5-HT as radioligand
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Optimization of the pharmacophore model for 5-HT7R antagonism. Design and synthesis of new naphtholactam and naphthosultam derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 7.97 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28056 | — | — | 1 | 8.40 |
| CHEMBL283065 | — | — | 1 | 7.90 |
| CHEMBL26907 | — | — | 1 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28056 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL283065 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL26907 | — | Ki | = | 25.12 | nM | 7.60 |