Assay Detail
Functional
CHEMBL620833
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Inhibition of cell growth of human epidermoid carcinoma xenograft (A431) model using cell based assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
6-Substituted-4-(3-bromophenylamino)quinazolines as putative irreversible inhibitors of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER-2) tyrosine kinases with enhanced antitumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 6.61 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90595 | — | — | 1 | 7.50 |
| CHEMBL328245 | — | — | 1 | 7.38 |
| CHEMBL329856 | — | — | 1 | 7.33 |
| CHEMBL327838 | — | — | 1 | 7.11 |
| CHEMBL91811 | — | — | 1 | 7.11 |
| CHEMBL91867 | — | — | 1 | 7.10 |
| CHEMBL93784 | — | — | 1 | 7.09 |
| CHEMBL328977 | — | — | 1 | 7.08 |
| CHEMBL94061 | — | — | 1 | 7.03 |
| CHEMBL92961 | — | — | 1 | 7.03 |
| CHEMBL328704 | — | — | 1 | 6.96 |
| CHEMBL92731 | — | — | 1 | 6.84 |
| CHEMBL93386 | — | — | 1 | 6.82 |
| CHEMBL94068 | — | — | 1 | 6.74 |
| CHEMBL91925 | — | — | 1 | 6.71 |
| CHEMBL2112370 | — | — | 1 | 6.65 |
| CHEMBL91009 | — | — | 1 | 6.57 |
| CHEMBL94062 | — | — | 1 | 6.50 |
| CHEMBL93783 | — | — | 1 | 6.48 |
| CHEMBL2112369 | — | — | 1 | 6.45 |
| CHEMBL442754 | — | — | 1 | 6.25 |
| CHEMBL93537 | — | — | 1 | 6.23 |
| CHEMBL92356 | — | — | 1 | 6.22 |
| CHEMBL419501 | — | — | 1 | 6.21 |
| CHEMBL94109 | — | — | 1 | 6.12 |
| CHEMBL93754 | — | — | 1 | 5.86 |
| CHEMBL316127 | — | — | 1 | 5.72 |
| CHEMBL92902 | — | — | 1 | 5.63 |
| CHEMBL92882 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90595 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL328245 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL329856 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL327838 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL91811 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL91867 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL93784 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL328977 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL94061 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL92961 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL328704 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL92731 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL93386 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL94068 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL91925 | — | IC50 | = | 194.0 | nM | 6.71 |
| CHEMBL2112370 | — | IC50 | = | 222.0 | nM | 6.65 |
| CHEMBL91009 | — | IC50 | = | 268.0 | nM | 6.57 |
| CHEMBL94062 | — | IC50 | = | 315.0 | nM | 6.50 |
| CHEMBL93783 | — | IC50 | = | 329.0 | nM | 6.48 |
| CHEMBL2112369 | — | IC50 | = | 353.0 | nM | 6.45 |
| CHEMBL442754 | — | IC50 | = | 564.0 | nM | 6.25 |
| CHEMBL93537 | — | IC50 | = | 589.0 | nM | 6.23 |
| CHEMBL92356 | — | IC50 | = | 598.0 | nM | 6.22 |
| CHEMBL419501 | — | IC50 | = | 616.0 | nM | 6.21 |
| CHEMBL94109 | — | IC50 | = | 756.0 | nM | 6.12 |
| CHEMBL93754 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL316127 | — | IC50 | = | 1891.0 | nM | 5.72 |
| CHEMBL92902 | — | IC50 | = | 2340.0 | nM | 5.63 |
| CHEMBL92882 | — | IC50 | = | 8500.0 | nM | 5.07 |