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Assay Detail

CHEMBL620836

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro inhibition of A431 (human carcinoma) cell basal growth.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A-431
Confidence 1 — Organism
Curated By Expert

Target

A-431 (CHEMBL614069)
Type CELL-LINE
Organism Homo sapiens

Publication

The combi-targeting concept: chemical dissection of the dual targeting properties of a series of "combi-triazenes".
Rachid Z, Brahimi F, Katsoulas A, Teoh N, Jean-Claude BJ.
J Med Chem (2003) 46 : 4313 -4321
PubMed 13678409 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 4.47 4.94

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL138125 1 4.94
CHEMBL137534 1 4.91
CHEMBL137617 1 4.80
CHEMBL133024 1 4.78
CHEMBL424093 1 4.70
CHEMBL137788 1 4.70
CHEMBL137189 1 4.63
CHEMBL332096 1 4.60
CHEMBL137635 1 4.60
CHEMBL344652 1 4.53
CHEMBL137364 1 4.48
CHEMBL136674 1 4.40
CHEMBL52765 1 4.35
CHEMBL343352 1 4.33
CHEMBL137027 1 4.30
CHEMBL336113 1 4.19
CHEMBL135592 1 4.05
CHEMBL133023 1 4.03
CHEMBL134312 1 4.00
CHEMBL136491 1 4.00
CHEMBL136492 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL138125 IC50 = 11400.0 nM 4.94
CHEMBL137534 IC50 = 12400.0 nM 4.91
CHEMBL137617 IC50 = 16000.0 nM 4.80
CHEMBL133024 IC50 = 16670.0 nM 4.78
CHEMBL424093 IC50 = 20000.0 nM 4.70
CHEMBL137788 IC50 = 20000.0 nM 4.70
CHEMBL137189 IC50 = 23220.0 nM 4.63
CHEMBL332096 IC50 = 25000.0 nM 4.60
CHEMBL137635 IC50 = 25140.0 nM 4.60
CHEMBL344652 IC50 = 29760.0 nM 4.53
CHEMBL137364 IC50 = 33000.0 nM 4.48
CHEMBL136674 IC50 = 40000.0 nM 4.40
CHEMBL52765 IC50 = 45000.0 nM 4.35
CHEMBL343352 IC50 = 47000.0 nM 4.33
CHEMBL137027 IC50 = 50290.0 nM 4.30
CHEMBL336113 IC50 = 65000.0 nM 4.19
CHEMBL135592 IC50 = 89460.0 nM 4.05
CHEMBL133023 IC50 = 93970.0 nM 4.03
CHEMBL134312 IC50 = 100000.0 nM 4.00
CHEMBL136491 IC50 = 100000.0 nM 4.00
CHEMBL136492 IC50 = 115900.0 nM -