Assay Detail
Functional
CHEMBL621042
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro antitumor activity against A375 (melanoma) human tumor cell lines.
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-375 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and antitumor activity of bicyclic and isomeric analogues of illudin M
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.96 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274328 | — | — | 1 | 8.40 |
| CHEMBL8039 | — | — | 1 | 7.75 |
| CHEMBL8312 | — | — | 1 | 7.50 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.16 |
| CHEMBL8350 | — | — | 1 | 6.89 |
| CHEMBL195491 | DEHYDROILLUDIN M | — | 1 | 6.26 |
| CHEMBL8640 | — | — | 1 | 6.00 |
| CHEMBL7993 | — | — | 1 | 5.70 |
| CHEMBL7994 | — | — | 1 | - |
| CHEMBL8744 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274328 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL8039 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL8312 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL8350 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL195491 | DEHYDROILLUDIN M | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL8640 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL7993 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL7994 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL8744 | — | IC50 | > | 10000.0 | nM | - |