Assay Detail
Binding
CHEMBL621525
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In vitro binding to 5-hydroxytryptamine 2C receptor using [125 I]-DOI
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacological characterization of a series of geometrically constrained 5-HT(2A/2C) receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.19 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116940 | — | — | 1 | 8.96 |
| CHEMBL119323 | — | — | 1 | 8.55 |
| CHEMBL6607 | BROLAMFETAMINE | 2.0 | 1 | 8.55 |
| CHEMBL445106 | — | — | 1 | 8.40 |
| CHEMBL331864 | — | — | 1 | 8.31 |
| CHEMBL263881 | LYSERGIDE | 2.0 | 1 | 8.26 |
| CHEMBL119584 | — | — | 1 | 7.96 |
| CHEMBL117689 | — | — | 1 | 7.47 |
| CHEMBL116209 | — | — | 1 | 7.23 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116940 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL119323 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL6607 | BROLAMFETAMINE | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL445106 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL331864 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL263881 | LYSERGIDE | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL119584 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL117689 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL116209 | — | Ki | = | 59.0 | nM | 7.23 |