Assay Detail
Functional
CHEMBL621834
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Inhibitory concentration required to decrease cell viability in cell growth culture against kidney cells ACHN
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | ACHN |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of 5-methyl-5-deaza nonclassical antifolates as inhibitors of dihydrofolate reductases and as potential antipneumocystis, antitoxoplasma, and antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.28 | 4.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL81820 | — | — | 1 | 4.64 |
| CHEMBL82975 | — | — | 1 | 4.15 |
| CHEMBL116614 | — | — | 1 | 4.04 |
| CHEMBL50514 | — | — | 1 | - |
| CHEMBL23532 | — | — | 1 | - |
| CHEMBL115788 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL81820 | — | IC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL82975 | — | IC50 | = | 70200.0 | nM | 4.15 |
| CHEMBL116614 | — | IC50 | = | 91400.0 | nM | 4.04 |
| CHEMBL50514 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL23532 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL115788 | — | IC50 | > | 112000.0 | nM | - |