Assay Detail
Functional
CHEMBL622599
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tubulin polymerization in human ovarian cancer cell lines
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Cancer cell lines |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of structurally highly modified analogues of the antimitotic natural product curacin A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.82 | 6.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2369027 | — | — | 1 | 6.19 |
| CHEMBL2369028 | — | — | 1 | 6.17 |
| CHEMBL89138 | CURACIN A | — | 1 | 6.14 |
| CHEMBL299279 | — | — | 1 | 6.13 |
| CHEMBL2369032 | — | — | 1 | 6.11 |
| CHEMBL2369025 | — | — | 1 | 6.11 |
| CHEMBL508496 | CURACIN B | — | 1 | 6.09 |
| CHEMBL264716 | — | — | 1 | 6.06 |
| CHEMBL2369033 | — | — | 1 | 6.04 |
| CHEMBL2369024 | — | — | 1 | 5.92 |
| CHEMBL2369026 | — | — | 1 | 5.82 |
| CHEMBL91937 | — | — | 1 | 5.68 |
| CHEMBL454328 | CURACIN C | — | 1 | 5.64 |
| CHEMBL2369022 | — | — | 1 | 5.48 |
| CHEMBL294903 | — | — | 1 | 5.34 |
| CHEMBL1714537 | — | — | 1 | 5.32 |
| CHEMBL2369023 | — | — | 1 | 5.27 |
| CHEMBL2115069 | — | — | 1 | 5.26 |
| CHEMBL91881 | — | — | 1 | - |
| CHEMBL88531 | — | — | 1 | - |
| CHEMBL56241 | — | — | 1 | - |
| CHEMBL89124 | — | — | 1 | - |
| CHEMBL2369020 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2369027 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL2369028 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL89138 | CURACIN A | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL299279 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL2369032 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL2369025 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL508496 | CURACIN B | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL264716 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL2369033 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL2369024 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2369026 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL91937 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL454328 | CURACIN C | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL2369022 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL294903 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL1714537 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL2369023 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL2115069 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL91881 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL88531 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL56241 | — | IC50 | > | 80000.0 | nM | - |
| CHEMBL89124 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2369020 | — | IC50 | > | 80000.0 | nM | - |