Assay Detail
ADMET
CHEMBL629683
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DBH (dopamine beta-hydroxylase) activity expressed as Ki value determined by degree to which compound inhibited conversion of tyramine to octopamine
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
1-(Thienylalkyl)imidazole-2(3H)-thiones as potent competitive inhibitors of dopamine beta-hydroxylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.79 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54434 | — | — | 1 | 7.60 |
| CHEMBL275322 | — | — | 1 | 7.59 |
| CHEMBL278068 | — | — | 1 | 7.22 |
| CHEMBL54906 | — | — | 1 | 6.80 |
| CHEMBL54500 | — | — | 1 | 6.32 |
| CHEMBL294141 | — | — | 1 | 6.13 |
| CHEMBL442739 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54434 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL275322 | — | Ki | = | 25.5 | nM | 7.59 |
| CHEMBL278068 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL54906 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL54500 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL294141 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL442739 | — | Ki | = | 1400.0 | nM | 5.85 |