Assay Detail
ADMET
CHEMBL632492
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of the increase of serum calcium levels in a dose-dependent fashion after subcutaneous infusion for 6 hr to TPTX rats at doses 0.20, 0.67, and 2 mg/kg/h
1
Total Activities
1
Compounds Tested
1
Activity Types
1
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Tissue | Serum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Nonpeptide alpha(v)beta(3) antagonists. 1. Transformation of a potent, integrin-selective alpha(IIb)beta(3) antagonist into a potent alpha(v)beta(3) antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 6.70 | 6.70 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| ROUTE | ROUTE | - | — | Subcutaneous |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL123262 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL123262 | — | IC50 | = | 200.0 | nM | 6.70 |