Assay Detail
ADMET
CHEMBL633441
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Tested for antimuscarinic potency on rat bladder
9
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Rattus norvegicus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Enantioselectivity of muscarinic antagonists. Isomeric 2-cyclohexyl-2-phenyl-5-[(dimethylamino)methyl]-1,3-oxathiolane methiodides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 7.93 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | 4.0 | 1 | 8.89 |
| CHEMBL45454 | — | — | 3 | 8.58 |
| CHEMBL45452 | — | — | 3 | 8.29 |
| CHEMBL45125 | — | — | 1 | 7.35 |
| CHEMBL40559 | — | — | 1 | 6.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | Kd | = | 1.288 | nM | 8.89 |
| CHEMBL45454 | — | Kd | = | 2.63 | nM | 8.58 |
| CHEMBL45452 | — | Kd | = | 5.129 | nM | 8.29 |
| CHEMBL45454 | — | Kd | = | 6.026 | nM | 8.22 |
| CHEMBL45452 | — | Kd | = | 8.913 | nM | 8.05 |
| CHEMBL45452 | — | Kd | = | 24.55 | nM | 7.61 |
| CHEMBL45454 | — | Kd | = | 35.48 | nM | 7.45 |
| CHEMBL45125 | — | Kd | = | 44.67 | nM | 7.35 |
| CHEMBL40559 | — | Kd | = | 123.03 | nM | 6.91 |