Assay Detail
ADMET
CHEMBL633442
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pA2 value is determined compared to standard H1-antagonists
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
New antihistamines: substituted piperazine and piperidine derivatives as novel H1-antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 7.96 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL505 | CHLORPHENIRAMINE | 4.0 | 1 | 8.40 |
| CHEMBL296419 | ASTEMIZOLE | 4.0 | 1 | 8.30 |
| CHEMBL553331 | — | — | 1 | 8.20 |
| CHEMBL17157 | TERFENADINE | 4.0 | 1 | 7.50 |
| CHEMBL305660 | EBASTINE | 4.0 | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL505 | CHLORPHENIRAMINE | Kd | = | 3.981 | nM | 8.40 |
| CHEMBL296419 | ASTEMIZOLE | Kd | = | 5.012 | nM | 8.30 |
| CHEMBL553331 | — | Kd | = | 6.31 | nM | 8.20 |
| CHEMBL17157 | TERFENADINE | Kd | = | 31.62 | nM | 7.50 |
| CHEMBL305660 | EBASTINE | Kd | = | 39.81 | nM | 7.40 |