Assay Detail
ADMET
CHEMBL633985
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In vivo antidiuretic antagonistic activity expressed as negative logarithm of the effective dose divided by the estimated volume of distribution (67 mL/kg).
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Tissue | Urine |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthetic antagonists of in vivo antidiuretic and vasopressor responses to arginine-vasopressin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 7.11 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265651 | — | — | 1 | 7.57 |
| CHEMBL267675 | — | — | 1 | 7.35 |
| CHEMBL414548 | — | — | 1 | 7.32 |
| CHEMBL216467 | — | — | 1 | 7.29 |
| CHEMBL438014 | — | — | 1 | 7.10 |
| CHEMBL263235 | — | — | 1 | 6.88 |
| CHEMBL437849 | — | — | 1 | 6.68 |
| CHEMBL438452 | — | — | 1 | 6.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265651 | — | Kd | = | 26.92 | nM | 7.57 |
| CHEMBL267675 | — | Kd | = | 44.67 | nM | 7.35 |
| CHEMBL414548 | — | Kd | = | 47.86 | nM | 7.32 |
| CHEMBL216467 | — | Kd | = | 51.29 | nM | 7.29 |
| CHEMBL438014 | — | Kd | = | 79.43 | nM | 7.10 |
| CHEMBL263235 | — | Kd | = | 131.83 | nM | 6.88 |
| CHEMBL437849 | — | Kd | = | 208.93 | nM | 6.68 |
| CHEMBL438452 | — | Kd | = | 213.8 | nM | 6.67 |