Assay Detail
Binding
CHEMBL636509
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In vitro binding affinity was determined against acetylcholinesterase from torpedo californica
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Torpedo californica |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Molecular docking studies of natural cholinesterase-inhibiting steroidal alkaloids from Sarcococca saligna.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 5.05 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL137039 | — | — | 1 | 5.58 |
| CHEMBL335133 | — | — | 1 | 5.52 |
| CHEMBL344593 | — | — | 1 | 5.39 |
| CHEMBL343780 | — | — | 1 | 5.27 |
| CHEMBL359415 | — | — | 1 | 5.04 |
| CHEMBL424100 | — | — | 1 | 4.97 |
| CHEMBL409854 | SALIGCINNAMIDE | — | 1 | 4.91 |
| CHEMBL146254 | — | — | 1 | 4.75 |
| CHEMBL422098 | — | — | 1 | 4.04 |
| CHEMBL343054 | — | — | 1 | - |
| CHEMBL413039 | — | — | 1 | - |
| CHEMBL147346 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL137039 | — | Ki | = | 2650.0 | nM | 5.58 |
| CHEMBL335133 | — | Ki | = | 3030.0 | nM | 5.52 |
| CHEMBL344593 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL343780 | — | Ki | = | 5400.0 | nM | 5.27 |
| CHEMBL359415 | — | Ki | = | 9050.0 | nM | 5.04 |
| CHEMBL424100 | — | Ki | = | 10700.0 | nM | 4.97 |
| CHEMBL409854 | SALIGCINNAMIDE | Ki | = | 12200.0 | nM | 4.91 |
| CHEMBL146254 | — | Ki | = | 17600.0 | nM | 4.75 |
| CHEMBL422098 | — | Ki | = | 90300.0 | nM | 4.04 |
| CHEMBL343054 | — | Ki | = | 134000.0 | nM | - |
| CHEMBL413039 | — | Ki | = | 126000.0 | nM | - |
| CHEMBL147346 | — | Ki | = | 216000.0 | nM | - |