Assay Detail
Binding
CHEMBL636648
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Inhibition of binding of 1 nM N6-[3H]cyclohexyladenosine to adenosine A1 receptor on rat cerebral cortical membranes.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Functionalized congeners of adenosine: preparation of analogues with high affinity for A1-adenosine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 8.23 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1512545 | — | — | 1 | 9.07 |
| CHEMBL604003 | — | — | 1 | 8.77 |
| CHEMBL606513 | — | — | 1 | 8.70 |
| CHEMBL1093910 | — | — | 1 | 8.64 |
| CHEMBL604839 | — | — | 1 | 8.60 |
| CHEMBL605042 | — | — | 1 | 8.60 |
| CHEMBL262083 | N6-PHENYLADENOSINE | — | 1 | 8.49 |
| CHEMBL604626 | — | — | 1 | 8.48 |
| CHEMBL604629 | — | — | 1 | 8.35 |
| CHEMBL605047 | — | — | 1 | 8.35 |
| CHEMBL605460 | — | — | 1 | 8.17 |
| CHEMBL604631 | — | — | 1 | 8.17 |
| CHEMBL605875 | — | — | 1 | 8.03 |
| CHEMBL605671 | — | — | 1 | 7.94 |
| CHEMBL606511 | — | — | 1 | 7.89 |
| CHEMBL604417 | — | — | 1 | 7.82 |
| CHEMBL606297 | — | — | 1 | 7.80 |
| CHEMBL605043 | — | — | 1 | 7.75 |
| CHEMBL605246 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1512545 | — | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL604003 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL606513 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL1093910 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL604839 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL605042 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL262083 | N6-PHENYLADENOSINE | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL604626 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL604629 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL605047 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL605460 | — | Ki | = | 6.8 | nM | 8.17 |
| CHEMBL604631 | — | Ki | = | 6.7 | nM | 8.17 |
| CHEMBL605875 | — | Ki | = | 9.3 | nM | 8.03 |
| CHEMBL605671 | — | Ki | = | 11.4 | nM | 7.94 |
| CHEMBL606511 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL604417 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL606297 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL605043 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL605246 | — | Ki | = | 210.0 | nM | 6.68 |