Assay Detail
Binding
CHEMBL636699
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Compound was evaluated for the inhibition of acetylcholinesterase activity from bovine erythrocytes after 0 minutes of incubation
7
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 8.28 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL341658 | — | — | 1 | 8.72 |
| CHEMBL208599 | HUPRINE X | — | 3 | 8.64 |
| CHEMBL140476 | HUPRINE Y | — | 2 | 8.52 |
| CHEMBL142491 | — | — | 1 | 8.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL341658 | — | IC50 | = | 1.91 | nM | 8.72 |
| CHEMBL208599 | HUPRINE X | IC50 | = | 2.31 | nM | 8.64 |
| CHEMBL140476 | HUPRINE Y | IC50 | = | 3.03 | nM | 8.52 |
| CHEMBL140476 | HUPRINE Y | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL142491 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL208599 | HUPRINE X | IC50 | = | 3.34 | nM | 8.48 |
| CHEMBL208599 | HUPRINE X | IC50 | = | 240.0 | nM | 6.62 |