Assay Detail
Binding
CHEMBL636700
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Compound was evaluated for the inhibition of acetylcholinesterase activity from bovine erythrocytes after 30 minutes of incubation
7
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 9.12 | 10.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140476 | HUPRINE Y | — | 2 | 10.61 |
| CHEMBL208599 | HUPRINE X | — | 3 | 10.17 |
| CHEMBL341658 | — | — | 1 | 9.30 |
| CHEMBL142491 | — | — | 1 | 8.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140476 | HUPRINE Y | IC50 | = | 0.0245 | nM | 10.61 |
| CHEMBL208599 | HUPRINE X | IC50 | = | 0.0674 | nM | 10.17 |
| CHEMBL208599 | HUPRINE X | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL341658 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL140476 | HUPRINE Y | IC50 | = | 0.64 | nM | 9.19 |
| CHEMBL142491 | — | IC50 | = | 3.58 | nM | 8.45 |
| CHEMBL208599 | HUPRINE X | IC50 | = | 350.0 | nM | 6.46 |