Assay Detail
Binding
CHEMBL636701
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for the inhibition of acetylcholinesterase of bovine erythrocytes
25
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.75 | 8.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140476 | HUPRINE Y | — | 3 | 8.94 |
| CHEMBL208599 | HUPRINE X | — | 3 | 8.89 |
| CHEMBL143290 | — | — | 1 | 8.61 |
| CHEMBL335355 | — | — | 1 | 8.58 |
| CHEMBL143094 | — | — | 1 | 8.45 |
| CHEMBL341658 | — | — | 3 | 8.17 |
| CHEMBL4524111 | — | — | 1 | 8.07 |
| CHEMBL322343 | — | — | 1 | 7.92 |
| CHEMBL109870 | — | — | 1 | 7.91 |
| CHEMBL139819 | — | — | 1 | 7.79 |
| CHEMBL322106 | — | — | 1 | 7.53 |
| CHEMBL109869 | — | — | 1 | 7.50 |
| CHEMBL325338 | — | — | 1 | 7.42 |
| CHEMBL357207 | — | — | 1 | 7.40 |
| CHEMBL142491 | — | — | 1 | 7.33 |
| CHEMBL322281 | — | — | 1 | 7.19 |
| CHEMBL395280 | HUPERZINE A | 2.0 | 1 | 7.13 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.89 |
| CHEMBL142816 | — | — | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140476 | HUPRINE Y | IC50 | = | 1.15 | nM | 8.94 |
| CHEMBL208599 | HUPRINE X | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL143290 | — | IC50 | = | 2.43 | nM | 8.61 |
| CHEMBL335355 | — | IC50 | = | 2.62 | nM | 8.58 |
| CHEMBL208599 | HUPRINE X | IC50 | = | 2.77 | nM | 8.56 |
| CHEMBL143094 | — | IC50 | = | 3.59 | nM | 8.45 |
| CHEMBL140476 | HUPRINE Y | IC50 | = | 4.23 | nM | 8.37 |
| CHEMBL341658 | — | IC50 | = | 6.73 | nM | 8.17 |
| CHEMBL341658 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL4524111 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL322343 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL109870 | — | IC50 | = | 12.4 | nM | 7.91 |
| CHEMBL139819 | — | IC50 | = | 16.2 | nM | 7.79 |
| CHEMBL322106 | — | IC50 | = | 29.8 | nM | 7.53 |
| CHEMBL109869 | — | IC50 | = | 31.4 | nM | 7.50 |
| CHEMBL325338 | — | IC50 | = | 38.5 | nM | 7.42 |
| CHEMBL357207 | — | IC50 | = | 39.6 | nM | 7.40 |
| CHEMBL142491 | — | IC50 | = | 46.4 | nM | 7.33 |
| CHEMBL322281 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL140476 | HUPRINE Y | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL395280 | HUPERZINE A | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL95 | TACRINE | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL341658 | — | IC50 | = | 139.0 | nM | 6.86 |
| CHEMBL142816 | — | IC50 | = | 257.0 | nM | 6.59 |
| CHEMBL208599 | HUPRINE X | IC50 | = | 402.0 | nM | 6.40 |