Assay Detail
Binding
CHEMBL636702
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Inhibition of acetylcholinesterase (AChE) in bovine erythrocyte(RBC)
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 2. Preparation and in vitro and in vivo evaluation of 1-(alkoxymethyl)-2-[(hydroxyimino)methyl]-3-methylimida zolium halides for reactivation of organophosphorus-inhibited acetylcholinesterases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.69 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33332 | — | — | 1 | 5.38 |
| CHEMBL33101 | — | — | 1 | 5.03 |
| CHEMBL32768 | — | — | 1 | 4.96 |
| CHEMBL32585 | — | — | 1 | 4.72 |
| CHEMBL34000 | — | — | 1 | 4.52 |
| CHEMBL416772 | — | — | 1 | 4.38 |
| CHEMBL288316 | — | — | 1 | 4.32 |
| CHEMBL284692 | — | — | 1 | 4.21 |
| CHEMBL289890 | — | — | 1 | - |
| CHEMBL748 | PRALIDOXIME CHLORIDE | 4.0 | 1 | - |
| CHEMBL33051 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33332 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL33101 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL32768 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL32585 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL34000 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL416772 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL288316 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL284692 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL289890 | — | IC50 | = | 139000.0 | nM | - |
| CHEMBL748 | PRALIDOXIME CHLORIDE | IC50 | = | 346000.0 | nM | - |
| CHEMBL33051 | — | IC50 | = | 126000.0 | nM | - |