Assay Detail
Binding
CHEMBL636705
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Concentration required to inhibit hydrolytic activity of bovine erythrocyte acetylcholinesterase by 50%
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-activity studies on a potent antagonist to organophosphate-induced toxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.73 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1204112 | — | — | 1 | 8.52 |
| CHEMBL1115 | PYRIDOSTIGMINE | 4.0 | 1 | 7.30 |
| CHEMBL1202156 | — | — | 1 | 5.16 |
| CHEMBL1202155 | — | — | 1 | 5.00 |
| CHEMBL1202157 | — | — | 1 | 4.85 |
| CHEMBL44034 | — | — | 1 | 4.70 |
| CHEMBL1202154 | — | — | 1 | 4.60 |
| CHEMBL290329 | — | — | 1 | - |
| CHEMBL298102 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1204112 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1115 | PYRIDOSTIGMINE | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1202156 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL1202155 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL1202157 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL44034 | — | IC50 | = | 20080.0 | nM | 4.70 |
| CHEMBL1202154 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL290329 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL298102 | — | IC50 | > | 100000.0 | nM | - |