Assay Detail
Binding
CHEMBL636711
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Inhibition of acetylcholinesterase (AChE)activity in bovine erythrocytes
23
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis, in vitro pharmacology, and molecular modeling of very potent tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 7.14 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4524111 | — | — | 3 | 8.46 |
| CHEMBL322343 | — | — | 3 | 8.35 |
| CHEMBL109870 | — | — | 1 | 7.91 |
| CHEMBL325338 | — | — | 3 | 7.56 |
| CHEMBL322106 | — | — | 1 | 7.53 |
| CHEMBL109869 | — | — | 1 | 7.50 |
| CHEMBL322281 | — | — | 3 | 7.33 |
| CHEMBL395280 | HUPERZINE A | 2.0 | 1 | 7.13 |
| CHEMBL322557 | — | — | 1 | 6.99 |
| CHEMBL109431 | — | — | 1 | 6.90 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.89 |
| CHEMBL323679 | — | — | 1 | 6.82 |
| CHEMBL323233 | — | — | 1 | 6.57 |
| CHEMBL111255 | — | — | 1 | 6.55 |
| CHEMBL111223 | — | — | 1 | 6.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4524111 | — | IC50 | = | 3.49 | nM | 8.46 |
| CHEMBL322343 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL4524111 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL322343 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL109870 | — | IC50 | = | 12.4 | nM | 7.91 |
| CHEMBL325338 | — | IC50 | = | 27.4 | nM | 7.56 |
| CHEMBL322106 | — | IC50 | = | 29.8 | nM | 7.53 |
| CHEMBL109869 | — | IC50 | = | 31.4 | nM | 7.50 |
| CHEMBL325338 | — | IC50 | = | 38.5 | nM | 7.42 |
| CHEMBL322281 | — | IC50 | = | 47.1 | nM | 7.33 |
| CHEMBL322281 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL395280 | HUPERZINE A | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL322557 | — | IC50 | = | 103.0 | nM | 6.99 |
| CHEMBL109431 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL95 | TACRINE | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL323679 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL323233 | — | IC50 | = | 267.0 | nM | 6.57 |
| CHEMBL111255 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL322281 | — | IC50 | = | 329.0 | nM | 6.48 |
| CHEMBL111223 | — | IC50 | = | 431.0 | nM | 6.37 |
| CHEMBL322343 | — | IC50 | = | 485.0 | nM | 6.31 |
| CHEMBL325338 | — | IC50 | = | 888.0 | nM | 6.05 |
| CHEMBL4524111 | — | IC50 | = | 1480.0 | nM | 5.83 |